<span class="center-menu">← <small>PREVIOUS: [[4.4. Immunological abnormalities]]</small> | <small>NEXT: [[5. Subtypes and Variants of POTS]]</small> →</span> -------- ##### Summary >[!Summary] >- ≥ 50% have neuropathic features[[#^1]] >- some have phosphorylated α-synuclein in skin biopsies, suggesting a neuropathic mechanism that may be shared with Parkinson disease and pure autonomic failure[[#^2]] -------- >*“At least half of patients with POTS have neuropathic features,” *<small>([[Thieben-2007]], [p. 6](zotero://open-pdf/library/items/5WXWEQWX?page=6&annotation=WS7XJH5E))</small>^1 >*“Some patients with POTS have phosphorylated α-synuclein in skin biopsies,36 suggesting a neuropathic mechanism that may be shared with Parkinson disease and pure autonomic failure.”* <small>([[Raj-2022]], [p. 3](zotero://open-pdf/library/items/YN8BG2FZ?page=3&annotation=LKDK9MNC))</small>^2